I have recently been working my way through Peter Kramer’s 1993 classic, Listening to Prozac: A Psychiatrist Explores Antidepressant Drugs and the Remaking of the Self . It has turned out to be quite different than I expected. I had run into the title in several histories of psychiatry (e.g., Anne Harrington’s Mind Fixers [2020]) and was generally under the—mistaken, I now realize—impression that the book fit squarely into the biologically-reductionist hype machine that surrounded the introduction of drugs like Prozac in the late 1980s and early 1990s. These days, it is quite common to look back on the early 1990s as a time of irrationally exuberant optimism about psychiatric medications, a kind of period of neo-Hippocratic humoral theory about serotonin (Kramer himself, somewhat ironically, I think, refers to serotonin and norepinephrine as “neurohumors”), a return of the repressed biological dimension to psychiatry and society writ large—when the Human Genome Project seemed to h...